%PDF-1.5
%
1 0 obj
<<
/Lang (en)
/MarkInfo <<
/Marked true
>>
/Metadata 2 0 R
/Outlines 3 0 R
/PageLayout /OneColumn
/PageMode /UseOutlines
/Pages 4 0 R
/StructTreeRoot 5 0 R
/Type /Catalog
/ViewerPreferences <<
/DisplayDocTitle true
>>
>>
endobj
6 0 obj
<<
/Author (Gemeinsamer Bundesausschuss/Federal Joint Committee \(g-ba.de\))
/Category (Nr. XXX \(S. XX XXX\))
/Comments (Anlage 1 zu TOP 08.1.5)
/Company (Gemeinsamer Bundesausschuss, \(www.g-ba.de\))
/CreationDate (D:20201005084654+02'00')
/Creator <4163726F626174205044464D616B65722031352066FC7220576F7264>
/Keywords <416E6E6578205849492085205265736F6C7574696F6E73206F6E207468652042656E65666974204173736573736D656E74206F66204D65646963696E616C2050726F64756374732077697468204E65772041637469766520496E6772656469656E7473204163636F7264696E6720746F2053656374696F6E20333561205347422056208520496E67656E6F6C204D656275746174650D0A2852656173736573736D656E742042656361757365206F66204E657720536369656E7469666963204B6E6F776C6564676529>
/ModDate (D:20201005084815+02'00')
/Producer (Adobe PDF Library 15.0)
/SourceModified (D:20201005064644)
/Subject (Pharmaceuticals Directive \(AM-RL\): )
/Title (Resolution)
>>
endobj
2 0 obj
<<
/Length 5002
/Subtype /XML
/Type /Metadata
>>
stream
2020-10-05T08:48:15+02:00
2020-10-05T08:46:54+02:00
2020-10-05T08:48:15+02:00
Acrobat PDFMaker 15 für Word
uuid:1ca62c23-8ff0-4865-b40d-13c86c2b4981
uuid:c2cf07cc-662e-407e-9cb6-5631f3a7a08c
7
application/pdf
Resolution
Pharmaceuticals Directive (AM-RL):
Gemeinsamer Bundesausschuss/Federal Joint Committee (g-ba.de)
Annex XII – Resolutions on the Benefit Assessment of Medicinal Products with New Active Ingredients According to Section 35a SGB V – Ingenol Mebutate
(Reassessment Because of New Scientific Knowledge)
Adobe PDF Library 15.0
Annex XII – Resolutions on the Benefit Assessment of Medicinal Products with New Active Ingredients According to Section 35a SGB V – Ingenol Mebutate
(Reassessment Because of New Scientific Knowledge)
D:20201005064644
Gemeinsamer Bundesausschuss, (www.g-ba.de)
Anlage 1 zu TOP 08.1.5
Nr. XXX (S. XX XXX)
Arzneimittel-Richtlinie (AM-RL):
endstream
endobj
3 0 obj
<<
/Count 8
/First 7 0 R
/Last 8 0 R
/Type /Outlines
>>
endobj
4 0 obj
<<
/Count 7
/Kids [9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R]
/Type /Pages
>>
endobj
5 0 obj
<<
/K 16 0 R
/ParentTree 17 0 R
/ParentTreeNextKey 14
/RoleMap 18 0 R
/Type /StructTreeRoot
>>
endobj
7 0 obj
<<
/A 19 0 R
/Count 2
/First 20 0 R
/Last 21 0 R
/Next 8 0 R
/Parent 3 0 R
/Title (Resolution)
>>
endobj
8 0 obj
<<
/A 22 0 R
/Count 4
/First 23 0 R
/Last 24 0 R
/Parent 3 0 R
/Prev 7 0 R
/Title <50696361746FAE20697320696E6469636174656420666F722074686520637574616E656F75732074726561746D656E74206F66206E6F6E2D68797065726B657261746F7469632C206E6F6E2D687970657274726F7068696320616374696E6963206B657261746F73697320696E206164756C74732E>
>>
endobj
9 0 obj
<<
/Contents [25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 35 0 R]
/CS1 [/ICCBased 36 0 R]
>>
/Font <<
/TT0 37 0 R
/TT1 38 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 0
/Tabs /S
/Type /Page
>>
endobj
10 0 obj
<<
/Annots [41 0 R]
/Contents [42 0 R 43 0 R 44 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
>>
/Font <<
/TT0 38 0 R
/TT1 45 0 R
/TT2 37 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 1
/Tabs /S
/Type /Page
>>
endobj
11 0 obj
<<
/Contents [46 0 R 47 0 R 48 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
>>
/Font <<
/TT0 45 0 R
/TT1 38 0 R
/TT2 37 0 R
/TT3 49 0 R
/TT4 50 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 2
/Tabs /S
/Type /Page
>>
endobj
12 0 obj
<<
/Contents [51 0 R 52 0 R 53 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
>>
/Font <<
/TT0 38 0 R
/TT1 45 0 R
/TT2 37 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 3
/Tabs /S
/Type /Page
>>
endobj
13 0 obj
<<
/Annots [54 0 R 55 0 R]
/Contents [56 0 R 57 0 R 58 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
/CS1 [/ICCBased 35 0 R]
>>
/Font <<
/C2_0 59 0 R
/TT0 45 0 R
/TT1 38 0 R
/TT2 37 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 4
/Tabs /S
/Type /Page
>>
endobj
14 0 obj
<<
/Annots [60 0 R 61 0 R]
/Contents [62 0 R 63 0 R 64 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
>>
/Font <<
/TT0 38 0 R
/TT1 45 0 R
/TT2 37 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 7
/Tabs /S
/Type /Page
>>
endobj
15 0 obj
<<
/Annots [65 0 R 66 0 R]
/Contents [67 0 R 68 0 R 69 0 R]
/CropBox [0.0 0.0 595.32 841.92]
/MediaBox [0.0 0.0 595.32 841.92]
/Parent 4 0 R
/Resources <<
/ColorSpace <<
/CS0 [/ICCBased 36 0 R]
/CS1 [/ICCBased 35 0 R]
>>
/Font <<
/TT0 45 0 R
/TT1 38 0 R
/TT2 37 0 R
>>
/XObject <<
/OL1 39 0 R
/OL2 40 0 R
>>
>>
/Rotate 0
/StructParents 9
/Tabs /S
/Type /Page
>>
endobj
16 0 obj
<<
/K [70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R
80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R
90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R
100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R 108 0 R 109 0 R
110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R
120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R
130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R
140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R
150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R
160 0 R]
/P 5 0 R
/S /Sect
>>
endobj
17 0 obj
<<
/Nums [0 [70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R null null 161 0 R null
null 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R]
1 [82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R
92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R
102 0 R 103 0 R 105 0 R null null 162 0 R null null 107 0 R 108 0 R
null 163 0 R null 164 0 R 103 0 R]
2 [109 0 R 110 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R
173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R
183 0 R 184 0 R 185 0 R 112 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R
192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R
202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R
212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R
222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 114 0 R 115 0 R 116 0 R]
3 [227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R
237 0 R 238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R
247 0 R 248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R
118 0 R 257 0 R 258 0 R null 259 0 R null 260 0 R null 261 0 R null
262 0 R null 263 0 R 264 0 R null 265 0 R 266 0 R null 267 0 R 268 0 R
null null 269 0 R 270 0 R null 271 0 R 272 0 R null 273 0 R 274 0 R
null 275 0 R 276 0 R null 277 0 R 278 0 R null 279 0 R null 280 0 R
281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R
291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R
120 0 R]
4 [301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R
null null 311 0 R null null 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R
128 0 R 129 0 R null 312 0 R 130 0 R 131 0 R 132 0 R 133 0 R]
5 312 0 R 6 312 0 R 7 [134 0 R 135 0 R null null 313 0 R null null 137 0 R 314 0 R 315 0 R
null 316 0 R 317 0 R null 318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R
324 0 R 325 0 R 326 0 R 327 0 R 140 0 R 141 0 R 142 0 R null null 328 0 R
null null 144 0 R 329 0 R 330 0 R null 331 0 R 332 0 R null 333 0 R
334 0 R 335 0 R 336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 341 0 R
343 0 R 146 0 R 147 0 R 148 0 R 149 0 R null 344 0 R null 345 0 R 326 0 R]
8 342 0 R 9 [null null 346 0 R null null 151 0 R 152 0 R 153 0 R 154 0 R 347 0 R
154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R]
10 347 0 R 11 347 0 R 12 164 0 R 13 345 0 R]
>>
endobj
18 0 obj
<<
/Annotation /Span
/Artifact /P
/Bibliography /BibEntry
/Chart /Figure
/Diagram /Figure
/DropCap /Figure
/Endnote /Note
/Footnote /Note
/InlineShape /Figure
/Outline /Span
/Strikeout /Span
/Subscript /Span
/Superscript /Span
/TextBox /Art
/Underline /Span
>>
endobj
19 0 obj
<<
/D [9 0 R /XYZ 69 771 0.0]
/S /GoTo
>>
endobj
20 0 obj
<<
/A 348 0 R
/Next 21 0 R
/Parent 7 0 R
/Title <6F6620746865204665646572616C204A6F696E7420436F6D6D69747465652028472D424129206F6E20616E20416D656E646D656E74206F662074686520506861726D61636575746963616C73204469726563746976652028414D2D524C293A20416E6E6578205849492085205265736F6C7574696F6E73206F6E207468652042656E65666974204173736573736D656E74206F66204D65646963696E616C2050726F64756374732077697468204E65772041637469766520496E6772656469656E7473204163636F7264696E6720746F2053656374696F6E20333561205347422056208520496E67656E6F6C204D65627574617465>
>>
endobj
21 0 obj
<<
/A 349 0 R
/Parent 7 0 R
/Prev 20 0 R
/Title (\(Reassessment Because of New Scientific Knowledge\))
>>
endobj
22 0 obj
<<
/D [10 0 R /XYZ 69 658 0.0]
/S /GoTo
>>
endobj
23 0 obj
<<
/A 350 0 R
/Next 351 0 R
/Parent 8 0 R
/Title (1. Additional benefit of the medicinal product in relation to the appropriate comparator therapy)
>>
endobj
24 0 obj
<<
/A 352 0 R
/Parent 8 0 R
/Prev 353 0 R
/Title (4. Treatment costs)
>>
endobj
25 0 obj
<<
/Length 37
/Filter /FlateDecode
>>
stream
x+*23P0bdBr.KB W
endstream
endobj
26 0 obj
<<
/Length 37
/Filter /FlateDecode
>>
stream
x+*23P0bdBr.KB W
endstream
endobj
27 0 obj
<<
/Length 2230
/Filter /FlateDecode
>>
stream
H\WKm
U
$2(Kx nUͣ+S,RԷ_??;/|xŏX;kVߥԏYG*#Y;~6wHczי!dÏPoerlro_9_l)~]01Kl)Km/纷6%HSyXD%/1`o
F{@'Au"ߘTe#(YGٹʣF|Y?)f;
,-5qz2*V's%@w0TEP悋5A;BҗBfc֍XpAFD,YSm()oA6/b-z2 jWnD+i[]gn|]vbeC&ϧglv&v)'] S@s
as^K.JYn[gWF-7mN[|>D }pP#i
tngO=8N[u[r?Xw|V.)A3qcr" w=鷛P?g|C=Ui q"g܊+#01 *D~m
5B"5)l(c x*^u~\-V=Y3vJϲzKۢc(~ϙoyό~u1$P_~%\il-yG> ÂN
D*,< W/Q&g~rtS+6)iUUڢߧN"Xr?:[68b:j}ʹh?9t" \;>,is`i~ %15u#LKɎsT`/9.P c6~Go#Nq^G. {f"%0PC=2h'c2S?*]e\8}VIH3!iN/^^iv8S#!G_jd C+ka